Pigment epithelium derived factor interviene en la regulación del metabolismo de los triglicéridos hepáticos en conejos hipercolesterolémicos inducidos por dieta y parcialmente revertidos mediante administración de aceite de oliva
Chronic diseases of adults are progressively increasing in developed and developing countries. A typical marker is hypercholesterolemia (HC) often associated with unhealthy eating habits. Our group developed a model of hypercholesterolemic rabbits exposed to diets rich in fat. We demonstrated that t...
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| Autores principales: | , , , |
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| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=14655 |
| Sumario: | Chronic diseases of adults are progressively increasing in developed and developing countries. A typical marker is hypercholesterolemia (HC) often associated with unhealthy eating habits. Our group developed a model of hypercholesterolemic rabbits exposed to diets rich in fat. We demonstrated that the increase of serum cholesterol at the expense of fatty diets promotes failures at the level of the seminiferous tubule with decreased tubular efficiency, apoptosis and deterioration of spermiogenesis. This is manifested by a decrease in the number of spermatozoa per ml of semen and an increase in abnormal forms (teratozoospermia). The incorporation of extra virgin olive oil (OO) to the diet promoted an attenuation or complete correction of seminal or sperm alterations. Using this model, it is of interest to analyze if alterations in Triglycerides (TG) are also produced in these animals. This would be evidenced both at the plasma level and by an increase in intracellular deposits in different organs, including the liver. The implication of PEDF (Pigment Epithelium Derived Factor), which through binding to its receptor ATGL (Adipose Trigliceride Lipase) activates the first step in the hydrolysis of triglycerides and the participation of the PPAR gamma pathway in this phenomenon, will be studied. The expression of mediators of this pathway will be determined in samples of control rabbits, hypercholesterolemics and protected by the addition of olive oil to their diet. |
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