Búsqueda de nuevas estrategias terapéuticas en dolor neuropático

Taking into account that the identification of novel molecules for effective treatment of inflammatory and immune diseases is one of the main present medical needs, and one of the major goals of the pharmaceutical industry, the aim of our work is intended to provide new therapeutic strategies and a...

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Detalles Bibliográficos
Autores principales: Coll, Roberto Carlos, Mariani, María Laura Lucía, Martínez, Maricel Anahí, Penissi, Alicia Beatríz
Publicado: 2019
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Acceso en línea:https://bdigital.uncu.edu.ar/fichas.php?idobjeto=14746
Descripción
Sumario:Taking into account that the identification of novel molecules for effective treatment of inflammatory and immune diseases is one of the main present medical needs, and one of the major goals of the pharmaceutical industry, the aim of our work is intended to provide new therapeutic strategies and a deeper understanding of the mechanism of action of new drugs related to neuropathic pain. Our research team will investigate if some natural and synthetic lactones developed by our laboratory inhibit rat peritoneal mast cell activation induced by proinflammatory neuropeptides. Biochemical, chemical, cell biology, and a variety of microscopic techniques will be used. These studies may contribute to new therapeutic strategies for neuropathic pain.