Imágenes cuantitativas de cerebro por resonancia magnética nuclear pesadas por difusión molecular
Diffusion-weighted-imaging (DWI) in magnetic resonance imaging (MRI) imaging (DWI) measures properties of water mobility to characterize the microstructure and its longitudinal changes in healthy and diseased brain studies. However, standard clinical DWI images do not reflect specific microstructura...
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| Autores principales: | , , , , , , , , , , , , |
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| Publicado: |
2019
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| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=14759 |
| Sumario: | Diffusion-weighted-imaging (DWI) in magnetic resonance imaging (MRI) imaging (DWI) measures properties of water mobility to characterize the microstructure and its longitudinal changes in healthy and diseased brain studies. However, standard clinical DWI images do not reflect specific microstructural properties, such as the diameters and orientations of axons, and therefore limit the biological and biomedical interpretation of the measurements. This project proposes to go beyond this limit based on a collaboration between the nuclear magnetic resonance spectroscopy and imaging (NMR-MRI) group of the Bariloche Atomic Center (CAB) and the MRI group of the University of Trento (UniTN). DWI methods will be optimized to determine diameters and orientations of axons in the structures of the white matter in the brain. The protocols will be implemented and evaluated in longitudinal studies in preclinical equipment (phantoms and mice in-vivo and ex-vivo in CAB, Argentina) and clinical (phantoms, healthy volunteers and ex vivo tissue in UniTN, Italy). At the end of the project it is expected to develop the bases for applications to the study of innovative biomarkers for Alzheimer's disease taking advantage of the active participation of UniTN in relevant multicentre studies. |
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