Estudio del dimorfismo sexual en la respuesta neuroquímica y neuroendocrina al estrés en ratas adultas expuestas prenatalmente a D-anfetamina
Amphetamines are psychostimulants that act on monoaminergic systems with a mechanism of action similar to that of cocaine. Its consumption has increased in the country in pregnancy. Psychoactive drugs can easily cross the placental barrier and reach the fetus to affect normal brain development. Expo...
Guardado en:
| Autores principales: | , , , , , |
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| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=14778 |
| Sumario: | Amphetamines are psychostimulants that act on monoaminergic systems with a mechanism of action similar to that of cocaine. Its consumption has increased in the country in pregnancy. Psychoactive drugs can easily cross the placental barrier and reach the fetus to affect normal brain development. Exposure to low doses of amphetamines or meta-amphetamine during pregnancy has long-term behavioral and neurochemical consequences that manifest themselves in adulthood, such as impaired locomotor activity, modifications in the synthesis and turnover of dopamine (DA), and changes in the number of dopaminergic receptors in the striatum and the nucleus accumbens. Stress is a critical factor that leads to pathological states such as depression or anxiety and is dependent on sex. There are similarities in the response to stress and the action of psychostimulant drugs at both the biochemical and behavioral levels. There is also a sexual dimorphism in the response to drugs of abuse such as psychostimulants. Although there is evidence that prenatal treatment with amphetamines regulates the activity of the stress axis and dopaminergic activity, the interaction of both has not yet been well studied. In particular, the effect of prenatal exposure with amphetamines and its impact on TIDA that exert an inhibitory tone on pituitary prolactin (PRL) has not been deepened. Dopaminergic neurons are regulated by endogenous opioid peptides that are widely distributed in the CNS and participate in the regulation of many functions such as the stress response, the action of psychostimulants and endocrine functions such as the control of PRL secretion. There is little evidence on the effects of prenatal exposure with psychostimulants on the opioid modulation of TIDA neurons and the hormonal response to stress in males and females. In this project we will study the neurochemical and neuroendocrine response to stress in adult male and female rats, with prenatal exposure to D-amphetamine. The dopaminergic activity in the HMB will be evaluated at HMB level in response to stress in male and female animals determining the expression of pTH, RD2 and DAT. The expression of opioid receptors and opioid precursors in HMB will be evaluated to study the role of the opioid system in the dopaminergic changes induced in response to stress in animals with intra-uterine exposure with amphetamines. |
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