Patrón génico de fibrosis y apoptosis en nefropatía obstructiva experimental :
Fibrosis and apoptosis gene pattern in experimental obstructive nephropathy: Rosuvastatin modulation Obstructive nephropathy renal disorder can be complex to treat due to the severe apoptosis and fibrosis. Previous studies shown that rosuvastatin (Ros), may have potential utility as a therapeuti...
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| Publicado en: | Revista Médica Universitaria |
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| Autores principales: | , , |
| Materias: | |
| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=3197 |
| Sumario: | Fibrosis and apoptosis gene pattern in experimental obstructive nephropathy:
Rosuvastatin modulation
Obstructive nephropathy renal disorder can be complex to treat due to the severe
apoptosis and fibrosis. Previous studies shown that rosuvastatin (Ros), may have
potential utility as a therapeutic option in kidney diseases which lead to apoptosis and
fibrosis.
Objective: to evaluate the possible antifibrotic and antiapoptotic effects of Ros during
experimental neonatal rats unilateral ureteral obstruction (UUO).
Materials and Methods: Neonatal rats were surgically obstructed (experimental group)
or not (control group), which were Ros treated or not (10 mg/kg per day) during 14
days. Subsequent nephrectomy and processing of the renal cortex to determinate by
RT-PCR technique, genes expression of inducible nitric oxide synthase (iNOS), heat
shock factor 1 (hsf1), heat shock protein 70 (hsp70), bax, bcl2, wt1, p53, snail, bone
morphogenetic protein (bmp7), E-cadherin, transforming growth factor (tgf-β) and
tumor necrosis factor (tnf-α).
Results: neonatal UUO induced fibrosis and apoptosis, while Ros treatment
modulated the fibrotic and apoptotic genes pattern and increased the bmp7, Ecadherin,
wt1, p53 and bcl2 expression as well as decreased the profibrotic and
proapoptotic genes expression (bax, tnf-α y tgf-β).
Our results allow us to suggest that Ros renal protection during UUO is linked to
hsp70 and nitric oxide bioavailability interaction, with concomitant decrease in pro
apoptotic gene pattern.
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