Garlic inhibitory effect on platelet activity induced by different agonists
Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its abili...
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Facultad de Ciencias Agrarias-UNCuyo
2021
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| Acceso en línea: | https://revistas.uncu.edu.ar/ojs3/index.php/RFCA/article/view/4644 |
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I11-R107article-46442021-07-07T00:37:00Z Garlic inhibitory effect on platelet activity induced by different agonists Garlic inhibitory effect on platelet activity induced by different agonists González, Roxana Elizabeth Soto, Verónica Carolina Sance, María Mirta Galmarini, Claudio Rómulo Allium sativum L. Perla INTA cultivar coagulación efecto antiagregatorio Allium sativum L. Perla INTA cultivar coagulation antiaggregatory effect Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its ability to inhibit platelet aggregation and thromboxane formation. The aim of this work was to evaluate the ability of garlic extracts to inhibit platelet aggregation induced by different agonists and their mixtures in different donors. Significant differences were found in platelet aggregation in response to each agonist (P ≤ 0.05). The highest antiaggregatory effect was observed with arachidonic acid and the lowest effect with collagen-arachidonic acid mixture. Interaction effects between donor and agonist (or mixtures) were detected. The study showed the potential of aqueous garlic extracts to prevent platelet aggregation induced by different agonist. Highlights Platelets play a central role in the progression of atherosclerotic lesions. Blood from nine non-smoker healthy donors was used for in vitro platelet aggregation study. Significant differences were found in platelet aggregation in response to each agonist. Aqueous garlic extracts could prevent platelet aggregation induced by different agonist. Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its ability to inhibit platelet aggregation and thromboxane formation. The aim of this work was to evaluate the ability of garlic extracts to inhibit platelet aggregation induced by different agonists and their mixtures in different donors. Significant differences were found in platelet aggregation in response to each agonist (P ≤ 0.05). The highest antiaggregatory effect was observed with arachidonic acid and the lowest effect with collagen-arachidonic acid mixture. Interaction effects between donor and agonist (or mixtures) were detected. The study showed the potential of aqueous garlic extracts to prevent platelet aggregation induced by different agonist. Highlights Platelets play a central role in the progression of atherosclerotic lesions. Blood from nine non-smoker healthy donors was used for in vitro platelet aggregation study. Significant differences were found in platelet aggregation in response to each agonist. Aqueous garlic extracts could prevent platelet aggregation induced by different agonist. Facultad de Ciencias Agrarias-UNCuyo 2021-07-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.uncu.edu.ar/ojs3/index.php/RFCA/article/view/4644 10.48162/rev.39.005 Revista de la Facultad de Ciencias Agrarias UNCuyo; Vol. 53 No. 1 (2021): January-June; 46-54 Revista de la Facultad de Ciencias Agrarias UNCuyo; Vol. 53 Núm. 1 (2021): Enero-Junio; 46-54 1853-8665 0370-4661 eng https://revistas.uncu.edu.ar/ojs3/index.php/RFCA/article/view/4644/3444 Derechos de autor 2021 Revista de la Facultad de Ciencias Agrarias UNCuyo https://creativecommons.org/licenses/by-nc-sa/3.0/deed.es |
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Universidad Nacional de Cuyo |
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Revistas en línea |
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Revistas en línea |
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Revista de la Facultad de Ciencias Agrarias |
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Revista de la Facultad de Ciencias Agrarias |
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I-11 |
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R-107 |
| language |
eng |
| format |
Online |
| author |
González, Roxana Elizabeth Soto, Verónica Carolina Sance, María Mirta Galmarini, Claudio Rómulo |
| spellingShingle |
González, Roxana Elizabeth Soto, Verónica Carolina Sance, María Mirta Galmarini, Claudio Rómulo Garlic inhibitory effect on platelet activity induced by different agonists Allium sativum L. Perla INTA cultivar coagulación efecto antiagregatorio Allium sativum L. Perla INTA cultivar coagulation antiaggregatory effect |
| author_facet |
González, Roxana Elizabeth Soto, Verónica Carolina Sance, María Mirta Galmarini, Claudio Rómulo |
| author_sort |
González, Roxana Elizabeth |
| title |
Garlic inhibitory effect on platelet activity induced by different agonists |
| title_short |
Garlic inhibitory effect on platelet activity induced by different agonists |
| title_full |
Garlic inhibitory effect on platelet activity induced by different agonists |
| title_fullStr |
Garlic inhibitory effect on platelet activity induced by different agonists |
| title_full_unstemmed |
Garlic inhibitory effect on platelet activity induced by different agonists |
| title_sort |
garlic inhibitory effect on platelet activity induced by different agonists |
| description |
Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its ability to inhibit platelet aggregation and thromboxane formation. The aim of this work was to evaluate the ability of garlic extracts to inhibit platelet aggregation induced by different agonists and their mixtures in different donors. Significant differences were found in platelet aggregation in response to each agonist (P ≤ 0.05). The highest antiaggregatory effect was observed with arachidonic acid and the lowest effect with collagen-arachidonic acid mixture. Interaction effects between donor and agonist (or mixtures) were detected. The study showed the potential of aqueous garlic extracts to prevent platelet aggregation induced by different agonist.
Highlights
Platelets play a central role in the progression of atherosclerotic lesions.
Blood from nine non-smoker healthy donors was used for in vitro platelet aggregation study.
Significant differences were found in platelet aggregation in response to each agonist.
Aqueous garlic extracts could prevent platelet aggregation induced by different agonist.
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| publisher |
Facultad de Ciencias Agrarias-UNCuyo |
| publishDate |
2021 |
| url |
https://revistas.uncu.edu.ar/ojs3/index.php/RFCA/article/view/4644 |
| topic |
Allium sativum L. Perla INTA cultivar coagulación efecto antiagregatorio Allium sativum L. Perla INTA cultivar coagulation antiaggregatory effect |
| topic_facet |
Allium sativum L. Perla INTA cultivar coagulación efecto antiagregatorio Allium sativum L. Perla INTA cultivar coagulation antiaggregatory effect |
| work_keys_str_mv |
AT gonzalezroxanaelizabeth garlicinhibitoryeffectonplateletactivityinducedbydifferentagonists AT sotoveronicacarolina garlicinhibitoryeffectonplateletactivityinducedbydifferentagonists AT sancemariamirta garlicinhibitoryeffectonplateletactivityinducedbydifferentagonists AT galmariniclaudioromulo garlicinhibitoryeffectonplateletactivityinducedbydifferentagonists |
| _version_ |
1800220930648047616 |
