Estudio de las propiedades antitumorales de tessaria absinthioides contra el melanoma
Between skin cancer diseases, specifically, related mortality rates related to melanoma are continuously increased. Despite melanoma have an incidence lower than 2%, it is responsible of more than 90% of skin cancer related deaths. Even though there are several approaches to melanoma treatment, dise...
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| Autores principales: | , , , , , |
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| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://bdigital.uncu.edu.ar/fichas.php?idobjeto=14476 |
| Sumario: | Between skin cancer diseases, specifically, related mortality rates related to melanoma are continuously increased. Despite melanoma have an incidence lower than 2%, it is responsible of more than 90% of skin cancer related deaths. Even though there are several approaches to melanoma treatment, disease incidence is increasing. Because of these, new more efficient therapeutic strategies are needed. Actually, the natural product use become interesting because its potential chemotherapeutic activity. T. absinthioides (Hook. & Arn.) DC is an aromatic plant currently used because its medicinal and culinary purposes. Its infusions have been used since Aymara and Huarpe traditional medicines because its anti-cholesterolemic, balsamic, expectorants, for the treatment of renal and hepatic insufficiencies, diabetes and ?empacho?. Studies realized in our laboratory have demonstrated the cytotoxic properties of T. absinthioides aqueous extract (TaAE) against human tumoral cell lines. Over no-tumoral cell lines, cytotoxicity was selectively reduced. Performed studies on laboratory animals allowed to demonstrate that TaAE oral administration do not induce acute or repeated dose toxicity (doses up to 2000 mg/kg and 1000 mg/kg/day, respectively), Moreover, the oral administration of TaAE at 300 mg/animal/day induce a significant increases in the median survival of animals with colorectal cancer. Recently, we studied the capability of TaAe to act synergistically with several chemotherapeutics. Carboplatin is one of the agents reported as synergistic. In accordance to the presented information, TaAE is a promising natural compound in the cancer treatment research. In particular, the current project propose to characterize chemically the TaAE, to describe its in vitro and in vivo activity against melanoma and to study the pharmacologic interaction with carboplatin. |
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